Castelo Branco assumes a very important role in the sub-regional connections of the center interior of the country. As one of the most important counties in the central region and one of the largest in the country, it has noticed a surge in local development, propitiated by the improvements made to the regional and local road network.

The main access roads are the A23 (Autoestrada da Beira Interior) which crosses the districts of Guarda, Castelo Branco, Portalegre, and Santarém, connecting Torres Novas (A1) to Guarda (A25), the IP2 (Itinerário Principal do Interior) and the IC8, favoring the connection to Coimbra. It is located 224 km from Lisbon (a 2h10m drive), 257 km from Oporto (a 2h35m drive), 141 km from Coimbra (a 1h35m drive), 387 km from Madrid (a 4h05m drive) and 142 km from Caceres (a 2h15m drive).

Castelo Branco is referenced as one of the medium-sized cities in the country with the best quality of life. The county has been the target of profound interventions in the scope of urban requalification and is served by energy and communications infrastructures, with excellent levels of quality.